In 1488, the Ottomans launched a major attack, from both land and sea: the navy was led by Hersekzade Ahmed Pasha, released from captivity, and the army by the governor of Rumeli, Hadim Ali Pasha. On this occasion, the Ottomans requested to the Venetians the use of Famagusta harbour to supply their troops by sea, but the Venetians rejected the request and even dispatched a fleet to Cyprus to guard against an Ottoman landing. The Mamluks also sought naval assistance from Italian powers, but were turned down as well.[8][10] The Ottoman fleet then moved to Alexandretta, hoping to intercept the Mamluk forces as they came up from Syria, while the Ottoman army, numbering some 60,000 men, secured control of Cilicia. Another great storm however destroyed the fleet, and the Mamluks were able to advance into Cilicia.[9][11][12] The two armies met at Ağaçarıyı near Adana on 26 August 1488. Initially, the Ottomans made good progress on their left, but their own right flank was driven back. When the Karaman soldiers fled the battlefield, the Ottomans were forced to retreat, conceding the field and the victory to the Mamluks.[12][13]
The Ottoman army withdrew to Karaman to regroup, suffering more casualties to attacks by the Turkmen tribes. Most of its provincial commanders were recalled to Istanbul and imprisoned in the Rumeli Hisar. In the meantime, the Mamluks laid siege to Adana, which fell after three months. Hersekzade Ahmed Pasha was able to achieve a minor victory in destroying a Mamluk detachment, but Cilicia was securely in Mamluk hands. More importantly, the Ottomans' Turkmen allies began to turn to the Mamluks, including Alaüddevle, thus restoring a line of Mamluk-oriented buffer states along the border.[11][12][14]
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