The relationship between the Ottomans and the Mamluks was adversarial: both states vied for control of the spice trade, and the Ottomans aspired to eventually taking control of the Holy Cities of Islam.[3] The two states however were separated by a buffer zone occupied by Turkmen states such as Karaman, Akkoyunlu, Ramazanoğlu and Dulkadir, which regularly switched their allegiance from one power to the other. Nevertheless, both the Venetian historian Domenico Malipiero and the Ottoman chronicler Tursun Bey report that as early as 1468, Mehmed II planned to campaign against the Mamluks in Syria, which was only averted by the refusal of Uzun Hassan and Karaman to cooperate, leading to the invasion and eventual annexation of his state by Mehmed.[4][5]
When Bayezid II ascended the Ottoman throne in 1481, his brother Cem, who enjoyed great support in Anatolia, rose up and contended with him for the throne. After he was defeated in battle, he sought refuge first in the Ramazanoğlu, and from there passed into Mamluk domains. Although the Mamluks declined to offer him any military support, this act aroused the hostility of Bayezid, which was further fanned when the Mamluks seized an Ottoman ambassador who was returning from Deccan with an Indian ambassador and gifts for the Ottoman Sultan.[3][6]
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